The system is epitope independent and can capture all phenotypes of CTCs (epithelial, mesenchymal and EMTing CTCs) as well as CTC clusters in a viable form (alive). The system is based on a microfluidic device that captures cells based on a combination of their size and compressibility. The Parsortix system enables a liquid biopsy (a simple blood test) to be used to provide the circulating metastatic breast cancer cells to the user in a format suitable for multiple types of downstream analyses. The standalone device, as indicated, does not identify, enumerate or characterize CTCs and cannot be used to make any diagnostic/prognostic claims for CTCs, including monitoring indications or as an aid in any disease management and/or treatment decisions. The end user is responsible for the validation of any downstream assay. The cells retained in the cassette are harvested by the Parsortix PC1 system for use in subsequent downstream assays. The system employs a microfluidic chamber (a Parsortix cell separation cassette) to capture cells of a certain size and deformability from the population of cells present in blood. The Parsortix ® PC1 system is an in vitro diagnostic device intended to enrich circulating tumor cells (CTCs) from peripheral blood collected in K 2EDTA tubes from patients diagnosed with metastatic breast cancer. Her characters are as deeply odd, imperfect, yet sympathetically human as any of those found in Barbara Gowdy’s short stories, and her knack for working hooks and twists into the tale – as with the opening sentence, which is only explained at book’s end – is balanced by a calm, crisp, Raymond Carveresque style that furthers the lure of her dreamlike, resonant world.ANGLE's Parsortix ® system is FDA cleared for its intended use in metastatic breast cancer and is currently the first and only FDA cleared medical device to harvest intact circulating cancer cells from blood. The strengths Caple showed in her first book, a short story collection, The Heart is its Own Reason (1998), are expanded here. The girls’ father Ivo, a painter, never leaves the house, and keeps painting over his only canvas after each new start their maternal grandmother, 62, takes up with her 26- year-old house painter and young Nadja secretly rents an apartment that she sneaks off to for scant hours just to be alone and read. Tragedy more than happiness defines their lives. Little is ordinary about the world Caple creates, or the clutch of characters that vividly inhabit it. Working in their parents’ bakery, which is attached to their home, their lives change suddenly when Josef, a 36-year-old widower and father, walks in and proceeds to charm and seduce Irma and captivate Nadja. The novel tells the story of 17-year-old Irma and her sister Nadja, who is almost 16. But it is the book’s pervading melancholy, Weltschmerz perhaps, a sense of life as tragedy leavened by occasional joy, imperfect love, and blind chance, that most strongly suggests this connection. That the characters in this intimate story of love’s compromises and life’s disappointments have names like Josef, Nadja, Irma, Ivo, and Adora adds to this impression. There’s a distinctly Eastern European feel to Toronto writer Natalee Caple’s debut novel, The Plight of Happy People in an Ordinary World.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |